A One's Cocker Spaniels

Familial Nepropathy (FN)/Progressiv Nefropati (PNP in Sweden)/Renal Failure/Juvenile Nephropathy -
We keep staggering in a mine-field.

Breeding Rule No 1: make combinations with as few carriers as possible in the first three generations and
NEVER approve of combinations where one carrier appears more than ONCE!

**Samples of renal tissue from one of the latest two dogs have been successfully reprocessed again by the Lees' team
and a definitive diagnosis of FN has been given for that dog! (May 31, 2005)

*2 cases of FN were reported to the UK Cocker Spaniel Club during 2004 (p 25 Year Book 2004) but, for the first time,
the names of the 4 carriers are not published in the Welfare Report (Issue 14 - March 2005). On page 2 in Issue 14 it says
"The Club will publish the names and registration number of all confirmed cases in the Annual Welfare Report.
Parentage will be published unless permission is expressly withheld."

"All animals are equal but some animals are more equal than others." (Orwell, Animal Farm)

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The first FN-case was officially reported in the 1930s. Who were the sire and dam? It is not likely that we will ever know which dog was the original mutant.

Was Butterfly of Broomleaf  (blue/roan/tan) an FN carrier? No reports of any of her children dying at a young age. If she was where it all started, or close to it, there wouldn't be enough dogs around which carried the mutation for it to have become apparent in litters within the first couple of generations. The original mutation must have occurred at least a generation or two back from the first recorded affected animals, because of the recessive nature of the problem.  Butterfly of Broomleaf is where the CROSS-OVER between solid and particoloured FN-cases occurred. IF she is an FN-carrier, then it would be reasonable to say that a dog which didn't trace its pedigree back to her would be unlikely to be a carrier..... providing that the pedigree is accurate!

Butterfly of Broomleaf (blue/roan/tan) appears behind both the solids and the particoloured pedigrees that are implicated in the disease. She is the grand dam of Black Friar of Broomleaf, who is the sire of Black Nun of Atway, who is the dam of Atway my Love of Misbourne who is the dam of Valjinxy of Misbourne, Loves Lisa of Misbourne (the grand dam of Perrytree Dark Memory!), Valswytch of Misbourne, Valdoonan of Misbourne, who is the grandsire of Olanza Pipistrelle, grand dam of Broomleaf Bright Memory. Black Nun of Atway is the great grand dam of Bronze Knight of Broomleaf, grandsire of Broomleaf Bright Memory. Butterfly of Broomleaf is also the dam of Broomleaf Black and Tan. Atway My Love of Misbourne is also full sister to Brioche of Broomleaf (grand dam of Butter Candy of Broomleaf, Broomleaf Bright Memory's dam).
Although in the distance, Butterfly of Broomleaf appears to have a heavy influence on the solid FN pedigrees.

Almost every particoloured FN-carrier pedigree seems to trace back to Ouaine Vivid Fairy of Ware, 1952-1964 (SHCH Joywyns Blue Boy of Ware & Merry Flirt of Ware)
She is sometimes 5 or 6 generations back, often a couple more in the distance.
Vivid Fairy is behind Adargi Joyful Girl of Classicway, Leabank Levity, Asquanne´s Niobe, Ouainé Merry Melanie, Bitcon Silver Rebel, Scolys Starduster, Coltrim of Örlidens, Ouaine Half A Dollar, Ouaine Silver Buck, Bitcon Dark Angel, Chrisolin Cambiare of Styvechale, Craigleith Troubadour, Keegans Glory of Coltrim, Harwenprince Evening Star, Deewell Senator, Travis Tribute To Helenwood, Travis Two Tribes, Mossdew Murphy's Law, Hightrees Sweet Talk of Lochranza, Cilleine Echelon, Ouainé Juryman, Ouainé Pandora, Ouainé Piccolina, Hilltops Silver Slipper, Ouainé Panderosa, Ouainé Chieftain, Falconers Envoy Of Ware, Ouaine Chipaway, Ouaine Cherry Blossom, Ouaine Gustav, Merryworth Mr Chips, Ouaine Cherry Blossom, Bitcon Make Believe, Atkia Alibaba, Jette Vom Köhlerwald, Ouaine Guelder Rose, Cochise Commander-In-Chief, Ouainé Gulliver, Örlidens Gay Match, Ouainé Diadem, Coltrim Cactus Flower, Matterhorn Masterpiece, Coltrim Mississippi Gambler, Ouainé Diogenes, Ouaine Juryman, Arclyon´s Aramis of Asquanne, Ouaine Parrandero, Maedown Macao, Britta Vom Riesengebirge, Ezra Vom Rauhen Holz and many others. Show me a particoloured FN pedigree, where she does NOT appear.

Ouaine Vivid Fairy of Ware is half sister to Goldenfields Minstrel Boy, to whom all particoloured FN-cases in the USA trace back.

Here is the pedigree of Joywyns Blue Boy of Ware:

Fantee Silver Sentinel	Cartref Critic	Falconer's Padlock of Ware	Sir Galahad of Ware
			Falconer's Careful
		Cartref Cloverleaf of Hearts	Harley Courtier
			Cartref Gay Model
	Headworker of Ware	Falconer's Mark of Ware	Falconer's Workman of Ware
			Falconer's Wisdom
		Colinwood Dainty	Feral of Halford
			Colinwood Cigarette
Cartref Charmer	Cartref Crown Agent	Czar of Cartref	Falconer's Padlock of Ware
			Cartref Cloverleaf of Hearts
		Blue Bonnet of Broomleaf	Bumble of Broomleaf
			Butterfly of Broomleaf
	Naseby Girl	Cartref Critic	Falconer's Padlock of Ware
			Cartref Cloverleaf of Hearts
		Cartref Collette	Cartref Gay Cavalier
			Cartref Clarinda

FN with no exception leads to the death of the afflicted dog. A painful death. To think that it has a genetic component which could be controlled to a degree,
if only there was a better dissemination of information pertaining to carriers of this problem, regardless of who the dog was sired by or was out of,
or how much they had won in the show ring. OK, be defensive when it comes to PRA, HD, or luxating patella. These problems often don't kill or seriously disable dogs,
but FN - there is NO CURE and NO TREATMENT and the dog WILL die! Try telling that to someone who owns just ONE beloved family member! IT IS PURE HELL!
The interests of the breed can only be best served when we all co-operate with each other and ensure that important pedigree information is shared and does not remain hidden away.

This list is NOT intended as an attack on certain dogs and certainly not on their breeders or owners! Nobody is to be blamed!
Unless relevant information is known but hidden.
This page should be regarded as one tool among others to guide you when you are planning a combination.
Which means watching out and not approving of combinations where one FN/PNP carrier appears more than ONCE!
And with as few carriers as possible in the first three, generations. Study the pedigrees and you will find that FN/PNP can (seem to) lurk for a very long time,
it can "skip" 7 or 8 generations ... or can it not? Of course FN can NOT "skip" one single generation!!! It is only the information that is skipped!

There are other types of kidney disease that might also affect English Cockers, but only FN/PNP is inherited.

A mutation based DNA test is up and running and until all dogs have been tested, in a 100 years or so, you are a CRIMINAL
if you do not go public with WHICH of your dogs is a carrier! And accordingly you should be banned from breeding for the rest of your life!
And ... better late than never, so DO IT, NOW!

What if FN is polygenic?

The dogs listed have been the registered parents of animals which have been given a
diagnosis within the diagnostic capabilites of the time.

** The dog died/is dying of FN, PNP (Sweden), ARHN, (Progressive) Renal Failure, Renal Dysplasia or Juvenile Nephropathy.
* The dog/bitch has produced stock that died/is dying of FN, PNP (Sweden), ARHN, (Progressive) Renal Failure, Renal Dysplasia or Juvenile Nephropathy.

Lucy, Nidawi a Touch of Magik, the day before she died

**Nidawi a Touch of Magik, Australia, born November 27, 2007, died at the age of 7 months. Diagnosis: "Chronic membranous glomerulonephritis with mineralisation".
Specialist veterinary pathologist's comments: "Presuming this is an English Cocker Spaniel, the lesions are consistent with hereditary nephritis."
NB! The sire has been tested CLEAR for FN.

**Panhur's Amazing Survivor, diagnosed PNP
Breeding rule number 1: NEVER approve of combinations where one carrier appears more than ONCE!

**March 2009: Young cocker born in 2008, died of PNP. Awaiting the SKK publishing

**King Wizard Lizzy born June 20, 2008, FN-testad free A (Antagene)

Bella

**Campbelldale China Doll, aka Bella, born October 16, 2007, Hunter Valley, Australia "diagnosed on May 16, 2008, progressive renal failure with her renal dysplasia.
Bella gave up her fight for life on April 15, 2009, in the loving arms of her owners, after 20.000 dollar had been spent to try and save her.

Australia: 3 pups died of renal failure at about 6, 9 and 14 months. The first was not autopsied. The second was, and the diagnosis gave an opinion that the problem WAS NOT inherited.
On the basis of that the bitch was mated again, the second litter born 20 May 2004. Shortly after the bitch was mated, a third dog from the original litter was diagnosed with renal failure.
Its autopsy said Juvenile Nephropathy, typical of the familial disease of Cocker Spaniels. A second opinion was sought and 4 of Australia's leading specialist pathologists concurred with the diagnosis.
Source: breeder of the litters & www.dogzonline.com.au
Below the pedigree of the pups:

**Nalle, born January 12, 1986, died of renal failure
Quettadene Insignia was born on January 28, 1984. His last litter was born on December 4, 1986.

Pedigree of FN-carrier *Yardew Rubens of Weirdene born June 29, 1976

Yardew Indigo	Yardew Scots Grey	CH Wells Fargo of Weirdene PRA Carrier	Weirdene Barnscar Fisher
			Weirdene Trench Zenda
		Yardew Dolly Grey	Glencora Moyhill Mallory
			Yardew Darnmill Dolly Daybreak
	Yardew Mallow	Glencora Moyhill Mallory	GBSHCH Colinwood Cobbler
			Moyhill Wise Girl of Kilbride
		Yardew Mollie Malone	Craigleith Oliver Thanks Special Branch!
			Yardew Darnmill Dolly Daydream Thanks Thanks Special Branch!
Yardew Floribunda	CH Ouainé Tomahawk	Leabank Laureate	Hightrees Forty Secrets
			Leabank Blue Mist
		Quainé Chickadee	Crackshill Tricolour of Ide
			Ouainé Panderosa
	Yardew Silver Leaf	*CH Scolys Starduster PRA Carrier too	Goldenfield's Minstrel Boy (CH Joywyns Blue Boy of Ware & Scoly's Solera)
			Scoly's Sweet Solera
		Yardew Conundrum	Ouainé Diogenes
			Yardew Connemara

All puppies in one litter died of Renal Failure, pedigreed below:

FN-case No 034

**Shadecock's Nadja, diagnosed PNP September 15, 2005, S21439/2004

**Solbo's Thiffany, blue roan/tan bitch, born June 5, 2003, diagnosed PNP on November 6, 2003
On January 5, 2004, a litter of 8 puppies out of Medeba's Dark Angel-Annie were born and registered at SKK, sired by ... Joycock's Royal Chocolate Love!!!!
And AGAIN, on January 23, 2004, another litter of 6 pups out of Swanmarks Beda were born and registered, sired by ... Joycock's Royal Chocolate Love!!!
AND AGAIN 7 puppies out of Swanmarks Beda were born on June 8, 2005, AND registered at SKK, sired by ... Joycock's Royal Chocolate Love!!!

**Allert's X Models, orange roan bitch born February 16, 2005, PNP diagnosis July 11, 2005

Los Ombues Carol, Spanish bitch, died of renal failure autumn of 2006, born September 24, 2005

FN-case No 76

FN-case No 109

**Tripol's Blue Button, Holland 1989

Holland, the combination below resulted in 2 FN-cases.

1974, Holland, 3 dogs from the same litter died of FN, pedigreed below:    Thanks LBD!

*Ouainé Chieftain	Crackshill Tricolour of Ide	CH Domino of Ide	CH Blue Flash of Ide (Cartref Contender & Merryworth Mayflower)
			Rodwood Lass of Sandover (Falconers Mark of Ware & Mareway Marie)
		Gaytime of Ide	Chayn Janitor (Nostrebor Chayn Weaver & Chayn Jennifer Gay)
			CH Rodwood Lass of Sandover (Falconers Mark of Ware & Mareway Marie)
	Ouainé Panderosa	CH Buryhill Cedar	CH Valstar Glow of Ide (CH Blue Flash of Ide & Cobnar Mist)
			CH Darnmill Dolly Blue (CH Joywyns Blue Boy of Ware & Darnmill Buryhill Pipistrelle)
		Ouainé Pandora	Dellah Merrymaker of Wykey (CH Joywyns Blue Boy of Ware & Dellah Merry Maid of Wykey)
			Ouainé Merry Melanie (CH Thornfalcon Fanfare of Ware & Ouainé Vivid Fairy of Ware daughter of CH Joywyns Blue Boy of Ware)
*Cochise Caitina	Lick Bla Benje	Westdyke Whirlwind	Westdyke Wildfire (Weirdene Barnscar Fisher & Chayn Amaryllis)
			Garrion Maid (Colinwood Cobbler & Lilibeth of Mountrath)
		Lick Bla Bennie	Chayn Janitor (Nostrebor Chayn Weaver & Chayn Jennifer Gay)
			Lick-Bla Betsy (Waterworth Bidar & Lick-Bla Binge)
	Cochise Circe	Wells Fargo of Weirdene PRA carrier	Weirdene Barnscar Fisher (Barnscar Ajax & Questing Seasprite)
			Weirdene Trech Zenda (Joywyns Blue Boy of Ware & Talwrn Riverbank Romana)
		Cochise Chiyoko	CH Colinwood Silver Lariot (Joywyns Blue Flash & Truslers Misty Morn)
			Cochise Giannina Mia (Glencora Blue Flash & Seta of Hy-Niall)

** Yunbeai Kindred Spirit W573145 & Yunbeai Kitty W573146 born May 11, 1980 (Western Australia)
Letter from Murdoch University to The Cocker Spaniel Club of Victoria (Australia) April 14, 1983 Page 1 Page 2 Page 3
The letter was sent to the Australian National Cocker Spaniel Council in 1983 but the letter was never published.

** Maragown Mercury 07087-1980 (New Zealand)

** 1981/2 (Western Australia)

** Lakanuki Hamlet, Isabella and Othello (all of which died of renal failure), born January 14, 1994 (Australia)

**Sofus First Price "Maggan" S45835/73 born August 25 1973, died at 13 months of PNP

**Vitahotellets Vildgräs, red bitch born Jan 14, 1997, died Nov 30 1998 of PNP, S23223/97

**Björkdalens Pia, born April 29, 1996, died of PNP Aug 28, 1996, red bitch S30405/96

**Prize's Designated Hitter, born on June 5, 2002, died of FN on 18 April 2003 (2 puppies out of 6 died in this litter.)

US FN case (advertised in the English Cocker Review)

**Line Sam Feels Nice S41420/93

Known cases of confirmed PNP (Sweden) - afflicted and carriers (published CT 4/93, 4/94 & 4/96):
Both parents of PNP afflicted dog are not to be bred with, nor are sons and daughters and full sisters and brothers.
Half brothers and sisters may be bred with if their total breeding qualities motivate this.
Båda föräldrarna till insjuknad hund tas ur avel liksom ev avkomma och helsyskon.
Halvsyskon kan användas i avel om deras totala avelsvärde motiverar det.
** PNP afflicted
* PNP carrier

Source: Some details have been published in the Hundsport Special and the Cockertidningen, www.rasdata.nu, at www.caras-cocker.de/cara_seite_2.htm
some reported from owners/breeders of affected dogs.

Kidney diseases - Thanks Lotte!

Familial Nephropathy (FN) in Cocker Spaniel Dogs (George E Lees)

FN versus PNP/RD (2006)

Pedigrees

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